FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) BIOSYNTHESIS
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General Information
Name
3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) BIOSYNTHESIS
Species
D. melanogaster
Symbol
PAPSB
FlyBase ID
FBgg0002058
Date last reviewed
2025-02-13
Number of members
4
Description
Description
3'-phosphoadenosine-5'-phosphosulfate (PAPS) is synthezised in the cytosol by the bifunctional enzyme Papss from sulfate and two molecules of ATP. It is either used in the cytosol or transported into the Golgi where it acts as sulfate donor for the sulfation of various molecules including proteins and glycosaminoglycan proteoglycans. (Adapted from PMID:31270211.)
Notes
Source Material
The 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) BIOSYNTHESIS Gene Group has been compiled using the following publication(s): Hirata et al., 2012, Goda et al., 2006, and Zhu et al., 2005 .
Key Gene Ontology (GO) terms
Biological Process
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Cellular Component
cytosol
Golgi apparatus
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Transport and synthesis of PAPS](https://reactome.org/PathwayBrowser/#/R-DME-174362)

[KEGG: Sulfur metabolism](https://www.kegg.jp/pathway/dme00920)

[KEGG: Purine metabolism](https://www.kegg.jp/pathway/dme00230)

[FlyCyc: sulfate activation for sulfonation](https://biocyc.org/pathway?orgid=DMEL&id=PWY-5340)

Synonyms and Secondary IDs
Synonym(s)
PAPSB
3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE (PAPS) BIOSYNTHESIS
PAPS biosynthesis
Secondary FlyBase ID(s)
References (4)