FB2026_03 , released September 17, 2026
Complex: MITOCHONDRIAL 4FE-4S ASSEMBLY COMPLEX
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General Information
Name
MITOCHONDRIAL 4FE-4S ASSEMBLY COMPLEX
Species
D. melanogaster
Symbol
ISA
FlyBase ID
FBgg0002072
Date last reviewed
2025-01-31
Number of members
2
Description
Description
The mitochondrial 4Fe-4S assembly complex scaffolds the ferrodoxin-dependent reductive 2Fe-2S cluster fusion to produce 4Fe-4S clusters. Downstream, 4Fe-4S clusters are incorporated into various proteins and are required for a variety of processes such as electron transfer, catalysis and structural roles. (Adapted from PMID:32817474.)
Notes on Group
Source Material
The MITOCHONDRIAL 4FE-4S ASSEMBLY COMPLEX Gene Group has been compiled using the following publication(s): Marelja et al., 2018 .
Key Gene Ontology (GO) terms
Molecular Function
iron-sulfur cluster chaperone activity
Biological Process
[4Fe-4S] cluster assembly
Cellular Component
mitochondrial [4Fe-4S] assembly complex
mitochondrial matrix
Related Gene Groups
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
ISA
MITOCHONDRIAL 4FE-4S ASSEMBLY COMPLEX
ISA complex
Mitochondrial iron-sulfur assembly complex
Secondary FlyBase ID(s)
References (2)