FB2026_03 , released September 17, 2026
Complex: RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX - TESTIS-SPECIFIC VARIANT
Open Close
General Information
Name
RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX - TESTIS-SPECIFIC VARIANT
Species
D. melanogaster
Symbol
PAF1C-T
FlyBase ID
FBgg0002094
Date last reviewed
2025-09-02
Number of members
5
Description
Description
Testis-specific RNA polymerase-associated factor 1 complex (tPAF) is a transcriptional regulator complex essential for Drosophila male germline development. tPAF facilitates expression of Y-linked male genes and promotes transcription termination to prevent aberrant expression via transcriptional read-through of X chromosome genes. (Adapted from FBrf0260702 and FBrf0263025).
Notes on Group

The testis specific variant of the RNA polymerase-associated factor 1 complex (tPAF) is composed of testis-specific paralog proteins of each of the four canonical PAF1 complex core proteins. Unlike the canonical complex, it has not been shown to associate with an Rtf1 family protein (FBrf0260702). Additionally, unlike the other genes encoding members of tPAF complex, the testis-specific Rtf1 paralog, Rtf1L, mutants showed no fertility defects, and Rtf1L did not colocalize with or coimmunoprecipitate tPAF proteins (FBrf0260702). FBrf0263025 suggests that Rtf1L is a component of tPAF by expression pattern, but does not test this and so is not included as a component of the gene group. Ski8 was shown to coimmunoprecipitate and colocalized tPAF (FBrf0260702). In the human PAF1 complex Ski8 is also part of canonical PAF1C (PMID:16024656).

Source Material
The RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX - TESTIS-SPECIFIC VARIANT Gene Group has been compiled using the following publication(s): Kai et al., 2025 and Vilstrup et al., 2024 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
PAF1C-T
RNA POLYMERASE-ASSOCIATED FACTOR 1 COMPLEX - TESTIS-SPECIFIC VARIANT
TPAF
tPAF
Secondary FlyBase ID(s)
References (3)