FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: PROTEIN O-MANNOSYLATION
Open Close
General Information
Name
PROTEIN O-MANNOSYLATION
Species
D. melanogaster
Symbol
POMAN
FlyBase ID
FBgg0002106
Date last reviewed
2025-03-20
Number of members
6
Description
Description
Protein O-linked mannosylation is a post-translational modification that occurs in the endoplasmic reticulum and is characterized by the attachment of a mannose to the hydroxyl group of serine or threonine residues of selected proteins via an α-glycosidic bond. In D. melanogaster, O-linked mannose is not further elongated to form more complex glycan structures. Mannosyltransferases rt and tw act together as a complex to O-mannosylate proteins such as dystroglycan Dg, while Tmtc1, Tmtc2, Tmtc3 and Tmtc4 are thought to specifically O-mannosylate cadherins. (Adapted from FBrf0258752.)
Notes
Source Material
The PROTEIN O-MANNOSYLATION Gene Group has been compiled using the following publication(s): Eisenhaber et al., 2021 and Ichimiya et al., 2004 .
Key Gene Ontology (GO) terms
Biological Process
protein O-linked glycosylation via mannose
Cellular Component
endoplasmic reticulum
Related Gene Groups
Parent group(s)
PROTEIN O-GLYCOSYLATION
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: O-linked glycosylation](https://reactome.org/PathwayBrowser/#/R-DME-5615637)

[KEGG: Mannose type O-glycan biosynthesis](https://www.kegg.jp/kegg-bin/show_pathway?dme00515)

[FlyCyc: protein O-mannosylation II (mammals, core M1 and core M2)](https://biocyc.org/pathway?orgid=DMEL&id=PWY-7922)

Synonyms and Secondary IDs
Synonym(s)
POMAN
protein O-linked mannose glycan biosynthesis
PROTEIN O-MANNOSYLATION
Secondary FlyBase ID(s)
References (3)