FB2026_02 , released June 18, 2026
Pathway: PROTEIN O-GalNAcYLATION
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General Information
Name
PROTEIN O-GalNAcYLATION
Species
D. melanogaster
Symbol
POGALN
FlyBase ID
FBgg0002109
Date last reviewed
2025-03-20
Number of members
12
Description
Description
Protein O-linked GalNAcylation is a post-translational modification that occurs in the Golgi apparatus. The synthesis of O-linked GalNAc glycans (also known as mucin-type O-glycans) begins with the attachment of a N-acetyl-galactosamine (GalNAc) via an α-glycosidic bond to the hydroxyl group of serine or threonine residues in secreted and membrane proteins; this monosaccharide O-glycan is known as the Tn antigen. The O-linked GalNAc can be extended by the addition of a galactose, forming the core 1 T antigen. A glucuronic acid can be further attached to the galactose resulting in the formation of a linear glycan. In D. melanogaster, Tn and T antigens are the most prevalent type of O-glycans and are involved in a broad range of processes, including cell recognition, adhesion and signaling. (Adapted from FBrf0244700 and FBrf0243014.)
Notes

The Pgant gene family contains 14 members; CG7304 and CG7579 are specifically expressed in the male accessory gland and are predicted to be enzymatically inactive as the catalytic residues are not conserved. As there is no functional information, CG10000, CG31776, CG7304 and CG7579 are not included in the gene list. The core 1 beta 1,3 galactosyltransferase gene family contains 11 members; CG34056, CG2975 and CG8708 has negligible core 1 beta 1,3 galactosyltransferase activity, while CG34057, tgy, CG3119, CG18558, CG2983, CG34451 and CG34452 lack functional information, therefore they were not included in the gene list. GlcAT-I and GlcAT-S are paralogs of GlcAT-P. As they are not involved in O-linked glycan biosynthesis, GlcAT-I and GlcAT-S are not included in the gene list.

Source Material
The PROTEIN O-GalNAcYLATION Gene Group has been compiled using the following publication(s): Zhang and Ten Hagen, 2019, Itoh et al., 2018, and Ten Hagen et al., 2003 .
Key Gene Ontology (GO) terms
Cellular Component
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (12)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
67b1629100002580
Synonyms and Secondary IDs
Synonym(s)
POGALN
mucin-type O-glycan biosynthesis
protein O-linked GalNAc glycan biosynthesis
PROTEIN O-GalNAcYLATION
Secondary FlyBase ID(s)
References (4)