The ATR-ATRIP DNA damage-sensing kinase complex is the master regulator of the DNA damage response controlling a signaling cascade required for the maintenance of genomic integrity. Activated by Replication Protein A complex-coated single-stranded DNA at the site of DNA double-strand breaks and stalled replication forks. (Adapted from Complex Portal.)
Notes on Group
The ATR-ATRIP DNA DAMAGE-SENSING KINASE COMPLEX was sourced from Complex Portal, curated by EMBL-EBI.
Source Material
The
ATR-ATRIP DNA DAMAGE-SENSING KINASE COMPLEX
Gene Group has been compiled using the following publication(s):
Brodsky et al., 2004
.
