Complex: TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE MOTOR COMPLEX

General Information

Name

TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE MOTOR COMPLEX

Species

D. melanogaster

Symbol

TIM23-MOTOR

FlyBase ID

FBgg0002164

Date last reviewed

2026-01-21

Number of members

Description

The TIM23 MOTOR (or TIM23 PAM) complex mediates import of mitochondrial presequence-containing proteins into the mitochondrial matrix. Following translocation of proteins across the outer mitochondrial membrane by the TOM complex, presequence-containing proteins are passed to the TIM23 MOTOR complex and transported across the inner membrane. This requires the ATPase-activity of the matrix subcomplex, the presequence translocase-associated motor (PAM). (Adapted from PMID:32074073,PMID:38828998 and PMID:19884344.)

Notes on Group

The TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE MOTOR COMPLEX represents a ubiquitously expressed set of complex subunits compiled using high-throughput expression data. Subunit paralogs with a strong testis expression bias

CG1724, Tim17a1, Tim17a2, Tim17b1, Tim17b2, ttm3, ttm2 have been excluded but can be found in the gene group TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX SUBUNITS.

Source Material

The TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE MOTOR COMPLEX Gene Group has been compiled using the following publication(s): Yoon et al., 2017, Žarsky and Doležal, 2016, Sugiyama et al., 2007, and Becker et al., 2001 .

Key Gene Ontology (GO) terms

Molecular Function

protein transporter activity

Biological Process

protein import into mitochondrial matrix

Cellular Component

mitochondrial inner membrane

Related Gene Groups

Parent group(s)

MITOCHONDRIAL PROTEIN IMPORT COMPLEXES

Members (7)

For all members: