FB2026_03 , released September 17, 2026
Pathway: GLYCINE CLEAVAGE SYSTEM
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General Information
Name
GLYCINE CLEAVAGE SYSTEM
Species
D. melanogaster
Symbol
GLYCLE
FlyBase ID
FBgg0002171
Date last reviewed
2025-01-27
Number of members
4
Description
Description
The catabolism of glycine via the glycine cleavage complex (GCS) occurs in the mitochondrion. It involves the decarboxylation and deamination of glycine into ammonia and carbon dioxide, and converts tetrahydrofolate to N5,N10-methylene tetrahydrofolate (5,10-CH2-THF). By producing the one carbon unit donor 5,10-CH2-THF, GCS is part of the folate cycle. (Adapted from PMID:18941301 and PMID:23615880.)
Notes
Source Material
The GLYCINE CLEAVAGE SYSTEM Gene Group has been compiled using the following publication(s): Zinke et al., 1999 .
Key Gene Ontology (GO) terms
Biological Process
glycine decarboxylation via glycine cleavage system
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
GO Causal Activity Model (GO-CAM)
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
689e7a5d00005099
Synonyms and Secondary IDs
Synonym(s)
GLYCLE
Glycine catabolism
GLYCINE CLEAVAGE SYSTEM
Secondary FlyBase ID(s)
References (3)