FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: L-METHIONINE SALVAGE PATHWAY
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General Information
Name
L-METHIONINE SALVAGE PATHWAY
Species
D. melanogaster
Symbol
LMETSA
FlyBase ID
FBgg0002175
Date last reviewed
2025-01-27
Number of members
5
Description
Description
L-methionine is an essential amino acid required for the synthesis of proteins, L-cysteine, and the methyl group donor S-adenosyl-L-methionine (SAM or AdoMet). The L-methionine salvage pathway, also known as the 5'-methylthioadenosine (MTA) cycle, occurs in the cytosol and is used to regenerate L-methionine from MTA, a by-product of the polyamine biosynthesis. In addition, the first reaction in the pathway produces adenine which can be used for purine nucleotide biosynthesis. (Adapted from PMID:31460700 and PMID:19946895.)
Notes

In D. melanogaster, the transaminase that converts 4-methylsulfanyl- 2-oxobutanoate to L-methionine has not yet been identified. CG31115 is a paralog of Mtap and is specifically expressed in testis. As there is no functional information, CG31115 is not included in the gene list.

Source Material
The L-METHIONINE SALVAGE PATHWAY Gene Group has been compiled using the following publication(s): Chou et al., 2014 .
Key Gene Ontology (GO) terms
Biological Process
L-methionine salvage
Cellular Component
cytosol
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
GO Causal Activity Model (GO-CAM)
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: S-methyl-5-thio-α-D-ribose 1-phosphate degradation I](https://biocyc.org/pathway?orgid=DMEL&id=PWY-4361)

[Reactome: Methionine salvage pathway](https://reactome.org/PathwayBrowser/#/R-DME-1237112)

[ KEGG:Cysteine and methionine metabolism](https://www.kegg.jp/pathway/dme00270)

Synonyms and Secondary IDs
Synonym(s)
LMETSA
5'-methylthioadenosine (MTA) cycle
L-METHIONINE SALVAGE PATHWAY
Secondary FlyBase ID(s)
References (3)