FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: L-LEUCINE CATABOLISM
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General Information
Name
L-LEUCINE CATABOLISM
Species
D. melanogaster
Symbol
LLEUCA
FlyBase ID
FBgg0002177
Date last reviewed
2025-01-27
Number of members
10
Description
Description
L-leucine is one of the three essential branched-chain amino acids (BCAAs) that is acquired from the diet. The catabolism of L-leucine occurs in the mitochondrion and involves several steps, including a transamination followed by a decarboxylation, which ultimately lead to the production of acetoacetate and acetyl-CoA. Acetyl-CoA can enter the tricarboxylic acid (TCA) cycle or be used for fatty acid biosynthesis, while acetoacetate is part of the ketone bodies metabolism. (Adapted from PMID:30485760.)
Notes
Source Material
The L-LEUCINE CATABOLISM Gene Group has been compiled using the following publication(s): Wu et al., 2025 .
Key Gene Ontology (GO) terms
Biological Process
L-leucine catabolic process
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
GO Causal Activity Model (GO-CAM)
Members (10)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[FlyCyc: L-leucine degradation I](https://biocyc.org/pathway?orgid=DMEL&id=LEU-DEG2-PWY)

[Reactome: Branched-chain amino acid catabolism](https://reactome.org/PathwayBrowser/#/R-DME-70895)

[KEGG: Valine, leucine and isoleucine degradation](https://www.kegg.jp/pathway/dme00280)

Synonyms and Secondary IDs
Synonym(s)
LLEUCA
L-LEUCINE CATABOLISM
L-leucine degradation
Secondary FlyBase ID(s)
References (3)