FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Pathway: L-LYSINE CATABOLISM
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General Information
Name
L-LYSINE CATABOLISM
Species
D. melanogaster
Symbol
LLYSCA
FlyBase ID
FBgg0002179
Date last reviewed
2025-01-27
Number of members
9
Description
Description
L-lysine is an essential amino acid acquired from the diet. The main catabolic route occurs in the mitochondria. It begins with the ε-deamination of L-lysine and proceeds via the intermediate metabolite L-saccharopine to produce acetyl-CoA. Acetyl-CoA can enter the tricarboxylic acid (TCA) cycle or be used for fatty acid biosynthesis. The pathway also produces the intermediates glutaryl-CoA and crotonyl-CoA which are the precursors for histone lysine glutarylation and crotonylation, respectively. (Adapted from PMID:28986444.)
Notes

The pipecolate pathway is an alternative catabolic route that begins with the α-deamination of L-lysine and proceeds via the intermediate metabolite L-pipecolate to produce acetyl-CoA. It is not clear if this pathway occurs in D. melanogaster as there are no orthologs for some of the enzymes known to be involved in this route. The enzyme catalysing the conversion of (S)-3-hydroxybutanoyl-CoA into acetoacetyl-CoA is not known in D. melanogaster.

Source Material
The L-LYSINE CATABOLISM Gene Group has been compiled using the following publication(s): St Clair et al., 2017 .
Key Gene Ontology (GO) terms
Biological Process
L-lysine catabolic process
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
AMINO ACID METABOLISM
GO Causal Activity Model (GO-CAM)
Members (9)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Other resource(s)
Note: The Drosophila pathways shown at these resources are computed using different methods. They may therefore differ from the manually curated and verified pathway shown above.

[Reactome: Lysine catabolism](https://reactome.org/PathwayBrowser/#/R-DME-71064)

[ KEGG:Lysine degradation](https://www.kegg.jp/pathway/dme00310)

Synonyms and Secondary IDs
Synonym(s)
LLYSCA
L-LYSINE CATABOLISM
L-lysine degradation
Secondary FlyBase ID(s)
References (3)