FB2026_02 , released June 18, 2026
Gene Group: THIOESTER-CONTAINING PROTEINS
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General Information
Name
THIOESTER-CONTAINING PROTEINS
Species
D. melanogaster
Symbol
TEP
FlyBase ID
FBgg0002209
Date last reviewed
2026-04-20
Number of members
4
Description
Description
Thioester-containing proteins (TEPs) are secreted proteins characterised by a highly conserved region TED (thiol ester-containing domain) found in vertebrate alpha2-macroglobulin. TEPs are protease inhibitors, acting as pseudo-substrates that are cleaved and form a covalent bond with proteases. (Adapted from FBrf0264427.)
Notes on Group

Mcr, macroglobulin-complement related, has been excluded from the THIOESTER-CONTAINING PROTEINS gene group as the critical cysteine residue of the thioester motif is replaced by serine (FBrf0264427).

Source Material
The THIOESTER-CONTAINING PROTEINS Gene Group has been compiled using the following publication(s): Cai et al., 2026 .
Key Gene Ontology (GO) terms
Molecular Function
metalloendopeptidase inhibitor activity
Biological Process
humoral immune response
Cellular Component
extracellular region
Related Gene Groups
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
TEP
THIOESTER-CONTAINING PROTEINS
Secondary FlyBase ID(s)
References (2)