FB2026_02 , released June 18, 2026
Pathway: KETOGENESIS
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General Information
Name
KETOGENESIS
Species
D. melanogaster
Symbol
KETOGENS
FlyBase ID
FBgg0002214
Date last reviewed
2026-05-18
Number of members
4
Description
Description
Acetoacetate, (R)-3-hydroxybutyrate ((R)-3-hydroxybutanoate), and acetone are the three ketone bodies produced in D. melanogaster, primarily in glia and the fat body. These serve as an important energy source during nutrient scarcity, such as starvation. Ketogenesis occurs in the mitochondrion, where acetyl-CoA derived from the beta-oxidation of fatty acids is used to produce acetoacetate and (R)-3-hydroxybutyrate. Acetone is formed by the spontaneous decarboxylation of acetoacetate. In addition, the catabolism of L-leucine and L-tyrosine may also contribute to acetoacetate production. (Adapted from PMID:28178565 and FBrf0252863.)
Notes

Acetoacetate and 3-hydroxybutanoate are thought to be exported into the extracellular space via transporters belonging to the monocarboxylate transporter (MCT) family. So far only, chk has been shown to be involved in acetoacetate export by cortex glia cells. The mitochondrial transporters are not known. Acat2 is a paralog of Acat1. As it is predicted to localize in the cytosol and there is no information for its involvement in ketone body metabolism, Acat2 is not included in the list.

Source Material
The KETOGENESIS Gene Group has been compiled using the following publication(s): Silva et al., 2022 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
69c59f8a00001827
Synonyms and Secondary IDs
Synonym(s)
KETOGENS
KETOGENESIS
ketone body biosynthesis
Secondary FlyBase ID(s)
References (3)