FB2026_02 , released June 18, 2026
Pathway: SULFIDE OXIDATION
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General Information
Name
SULFIDE OXIDATION
Species
D. melanogaster
Symbol
SULOXID
FlyBase ID
FBgg0002230
Date last reviewed
2026-05-18
Number of members
4
Description
Description
Hydrogen sulfide (H2S) catabolism, known as sulfide oxidation, occurs in mitochondria where H2S is converted to sulfate. Sulfate is used for the cytosolic production of 3'-phosphoadenosine-5'-phosphosulfate (PAPS), a sulfate donor for the sulfation of glycoproteins. (Adapted from FBrf0259145.)
Notes

Sqor, which catalyzes the first step in sulfide oxidation, can use various substrates as sulfur acceptors, including glutathione and sulfite; however, glutathione is likely the most used. Tst1, a putative thiosulfate:glutathione sulfurtransferase, may contribute to the production of S-sulfanylglutathione (GSSH) from thiosulfate; however, as there is no experimental evidence, Tst1 is not included in the gene list. Dic2, Dic3 and Dic4 are paralogs of Dic1. Dic2, Dic3 and Dic4 are specifically expressed in the testis. Dic4 appears to lack transport activity and Dic2 lacks functional information. Therefore, Dic2, Dic3 and Dic4 are not included in the gene list.

Source Material
The SULFIDE OXIDATION Gene Group has been compiled using the following publication(s): Martelli et al., 2024 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (4)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
69d8496c00000431
Synonyms and Secondary IDs
Synonym(s)
SULOXID
hydrogen sulfide catabolism
H2S catabolism
SULFIDE OXIDATION
Secondary FlyBase ID(s)
References (3)