Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mapA using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\mapA in JBrowse2-82
Based on 7 recombinants between Amy and mapA.
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
One of two closely linked genes (see also mapP) that determines the pattern of α-amylase activity in three contiguous segments of the anterior portion of the adult midgut (mapA) and two segments of the posterior portion of the adult midgut (mapP). The short non-digestive middle midgut is without amylase activity in any genotype. mapP has three known alleles and mapA appears to have five since all 15 possible haplotypes have been reported (Doane, 1980). In most cases, the pattern observed in the larval midgut is different from that seen in the adult of the same genotype. A pattern in which all three anterior segments and both posterior segments exhibit enzyme activity is designated 123-12 and one with no activity 000-00. The pattern observed is affected both by nutrition and adult age; for example, in some strains a 123-00 pattern may change to a 123-12 pattern at approximately 14 days of age in adults; in other strains, this change does not occur (Doane, Treat-Clemons, Gemmill, Levy, Hawley, Buchberg and Paigen, 1983). <up>Additional, as yet unnamed, genetic factors control amylase patterns in the anterior midgut and posterior midgut of larvae (Treat-Clemons and Doane, 1983; Klarenberg, Visser, Willemse and Scharloo, 1986); one is a cis-regulator of amylase activity in the anterior midgut and is located within 0.1 cM of Amy (Klarenberg et al., 1986)</up>.
The anterior adult midgut is divided into three segments which express discreet patterns of amylase activity.
Different mapA alleles exhibit enzyme activity in different combinations of the three segments of the anterior midgut. Presence of activity in the three regions is designated, from anterior to posterior, 1, 2 and 3; absence or near absence of activity in any region is designated 0; these notations appear as three-digit superscripts in mapA allelic designations.
