PurR
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pur-r using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pur-r in JBrowseMap position approximate.
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gene dosage experiments are inconsistent with the notion that Pur-r represents the structural locus for ADA and indicate instead that Pur-r encodes a negative regulator of ADA. This view is supported by biochemical studies, which indicate that Pur-r+ encodes a thermolabile component that inhibits ADA activity, presumably analogous to the ADA-binding protein known in mammalian systems (Daddona and Kelley, 1980, Mol. Cell Biochem. 29: 91--101).
Identification and initial characterisation of one 2,6-diaminopurine (DAP)-resistant mutation, Pur-r, which appears to encode a trans-acting regulator of adenosine deaminase enzyme activity.
