Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\r(αGPDH) using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\r(αGPDH) in JBrowse3-55.08 +/- 0.99
3-55.4
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Recessive allele of a locus that affects levels of αglycerol phosphate dehydrogenase activity. In the presence of the dominant allele, which Lindsley and Zimm (1992) designated r(αGPDH)+, αGPDH levels in the adult are 60% higher than they are in r(αGPDH) homozygotes; the increase is observed in the thorax but not the abdomen. Rates of enzyme synthesis the same in the two genotypes; differences in activity attributed to reduced rates of degradation in the presence of r(αGPDH)+; no evidence for conformational differences in αGPDH. Not a general regulator of enzyme activity; however one rapidly migrating polypeptide is much more abundant in r(αGPDH) homozygotes than in the presence of r(αGPDH)+. Larvae carrying r(αGPDH)+ have 25% lower levels of αGPDH activity than r(αGPDH) homozygotes.
