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FB2026_01
,
released March 12, 2026
Stellate 1, Stellate 2, Stellate, Ste, hSte
ß subunit of Casein kinase II - a normally inactive gene which, when active, leads to male sterility - a target of post-transcriptional gene regulation
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SteXh using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\SteXh in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Heterochromatic cluster containing Stellate repeats, cause PEV of a reporter mini-w gene.
The structure and molecular diversity of the 30kb SteXh cluster in the distal heterochromatin of the X chromosome has been determined. The cluster comprises approximately 20 copies of tandemly repeated Stellate genes, 10 of which have been sequenced. Nine of these contain undamaged open reading frames which have extensive similarity to the CkIIβ gene. The cluster is divided into three regions by a 4.5kb DNA segment of unknown origin and a GATE retrotransposon insertion: the A region (containing approximately 14 Stellate genes), the adjacent B region (containing approximately 3 Stellate genes), and the C region (containing approximately 4 Stellate genes).
60kb repeats located in the distal heterochromatin of the X chromosome have been cloned. These regions, designated as SCLRs, are comprised of the following types of repeated elements: SteXh, copia-like elements (mdg1 elements, aurora-elements and GATE elements), LINE-elements (G-elements and R1-elements), and bb fragments. There are approximately 9 SCLR copies per haploid genome, with a twofold variation in copy number between different fly stocks.
The relationship of Ste copy number and organisation to meiotic behaviour in Su(Ste)- males has been examined genetically and cytologically. Heterochromatic and euchromatic Ste repeats are functional, the abnormalities in chromosome condensation and frequency of nondisjunction is related to the Ste copy number. Meiosis is disrupted after synapsis and Su(Ste) induced meiotic drive is probably not mediated by Ste.
Two variants of X chromosome Stellate genes occupy different genome positions. The majority of 1250bp Stellate repeats map at 12E (location of Ste) but almost all of the 1150bp Stellate repeats are in the distal X heterochromatin (at SteXh). Some of the heterochromatic copies are expressed.