FlyBase Gene Report: Dana\Om(2D)

Important message

Updated sequence information for this Drosophila species is no longer provided by FlyBase. Gene model annotations for this species are now updated and maintained at NCBI, using the gnomon automated annotation pipeline. See the NCBI page ‘Eukaryotic genomes annotated at NCBI’.

The FlyBase BLAST tool will continue to support queries against the reference genome of this species, but not queries against annotated transcripts or proteins. For the current release, there is no JBrowse or GBrowse view of the gene model annotations for this species.

The FlyBase archived release FB2017_05 includes the last NCBI annotation update for this species that was imported into FlyBase. That sequence data can be accessed from archived gene reports, via the archived GBrowse tool, and via archived bulk-data downloads.

General Information

Symbol

Dana\Om(2D)

Species

D. ananassae

Name

Optic morphology(2D)

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010400

Gene Model Status

Withdrawn

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Summaries

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dana\Om(2D)

Transgenic constructs containing regulatory region of Dana\Om(2D)

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Dana\Ab(2)Dana\Om(2D)^63R28

(Matsubayashi et al., 1991)

Dana\Df(2R)Om(2D)^63R6

(Tanda et al., 1993, Matsubayashi et al., 1991)

Dana\Df(2R)Om(2D)^63R23

(Tanda et al., 1993, Matsubayashi et al., 1991)

Dana\T(2;3)Om(2D)^63R5

(Tanda et al., 1993, Matsubayashi et al., 1991)

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

lethal - all die during embryonic stage | recessive

viable

Dana\Om(2D)^63R5

Other Phenotypes

Allele

abnormal visual behavior

some die during embryonic stage | recessive

some die during larval stage | recessive

visible

Dana\Om(2D)⁶³

visible | dominant

Dana\Om(2D)^63E8

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

gene

ncRNA_gene

(FlyBase Consortium, 2015)

nuclear_gene

(Drosophila 12 Genomes Consortium, 2008)

protein_coding_gene

(FlyBase Consortium, 2015, Drosophila 12 Genomes Consortium, 2008)

Stocks and Reagents

Stocks (0)

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Non-coding transcripts added to the protein coding annotation GF10000 in release 1.04 of the genome annotation.

(FlyBase Consortium, 2015)

Dana\Om(2D) gene encodes a novel protein containing His/Pro repeats and is ubiquitously expressed during embryogenesis. RNA is abundantly found in the centre of the eye discs of Dana\Om(2D) mutants, where excessive cell death occurs.

(Yoshida et al., 1994)

Genetically mapped, but location given in terms of cytology as 48B.

(Matsubayashi et al., 1992)

Identified during study of a hypermutable system, where mutants with defective optic morphology were isolated (Hinton, Genetics 106: 631--653).

(Matsubayashi et al., 1992)

Dana\Om(2D) is subjected to histological and molecular analysis as a step toward understanding the role of optic morphology (Om) genes in eye morphogenesis.

(Matsubayashi et al., 1991)

The eyes lozenge shaped or sometimes broadly concave at the anterior margin. The most conspicuous effect of these mutants extends across the middle half of the eye: this roughly grained area contains no distinct ommatidia or interommatidial bristles.

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dana\Om(2D)

(FlyBase Consortium, 2015, Drosophila 12 Genomes Consortium, 2008)

GF10000

(FlyBase Consortium, 2015)

Om(2D)

(Drosophila 12 Genomes Consortium, 2008)

dana_GLEANR_10675

(Drosophila 12 Genomes Consortium, 2008)

Name Synonyms

Optic morphology(2D)

(Matsubayashi et al., 1992)

Secondary FlyBase IDs

FBgn0012125

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 15 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

6507952

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

FlyMine - An integrated database for Drosophila genomics

FBgn0010400

GNOMON -

Dana_gnomon_100_gene.8410466

InterPro - A database of protein families, domains and functional sites

References (16)

Important message

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