FlyBase Gene Report: Dhaw\Adh

General Information

Symbol

Dhaw\Adh

Species

D. hawaiiensis

Name

Alcohol dehydrogenase

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0012345

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

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All Summaries

Alliance
Auto summary
Interactive Fly

Summaries

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

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Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dhaw\Adh

Transgenic constructs containing regulatory region of Dhaw\Adh

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P51549 )

Linkouts

Class of Gene

gene

protein_coding_gene

(FlyBase curators, 2018-)

Stocks and Reagents

Stocks (0)

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Naturally occurring tissue-specific regulatory differences for Dhaw\Adh gene are mapped to three regions within the 840bp promoter region.

(Fang and Brennan, 1992)

Deletion and chimeric analysis of the Daff\Adh cis-acting sequences has been performed to examine the higher level of Daff\Adh expression in the larval midgut and larval Malpighian tubules than Dhaw\Adh.

(Fang et al., 1991)

Tissue specific patterns of Adh expression were studied by comparing D.melanogaster transformants that carry Adh genes from D.affinidisjuncta, D.hawaiiensis and D.grimshawi. Northern blot analysis and gel electrophoresis of transformant larvae carrying the D.affinidisjuncta and D.grimshawi Adh gene show comparable high levels of expression and broader tissue distribution of Adh expression, transformants carrying the D.hawaiiensis Adh gene show reduced levels of each.

(Wu et al., 1990)

Daff\Adh and Dhaw\Adh display markedly different levels of alcohol dehydrogenase in the larval midgut and Malpighian tubules. Comparison of the expression of Daff\Adh and Dhaw\Adh in transgenes in D.melanogaster demonstrates that the tissue specific levels of alcohol dehydrogenase are characteristic of the genes themselves. Demonstrable differences in cis-dominant regulatory information are sufficient to account for the observed regulatory variation.

(Brennan et al., 1988)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Adh

Dhaw\Adh

Name Synonyms

Alcohol dehydrogenase

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 7 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

U48715

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAB40356

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P51549

Other crossreferences

InterPro - A database of protein families, domains and functional sites

References (10)

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