FlyBase Gene Report: Dmul\Adh2

General Information

Symbol

Dmul\Adh2

Species

D. mulleri

Name

Alcohol dehydrogenase-2

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0012582

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

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All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Adh, Adh-2

Summaries

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dmul\Adh2

Transgenic constructs containing regulatory region of Dmul\Adh2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homodimer.

(UniProt, P07160 )

Linkouts

Class of Gene

gene

protein_coding_gene

(FlyBase curators, 2018-)

Stocks and Reagents

Stocks (0)

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The phylogenetic relationships and divergence times of 39 drosophilid species have been studied by using the coding region of the Adh gene.

(Russo et al., 1995)

The srp-binding sites of the D.melanogaster and D.mulleri Adh larval promoters function as positive control elements.

(Abel et al., 1993)

Phylogenetic DNA sequence comparison of ten Drosophila species has been used to elucidate the secondary structure of Adh mRNA. One possible pairing region in the 5' leader sequence and 22 in the coding and noncoding regions have been identified by seeking an equivalent pairing region in homologous RNA. Most are short range pairings such as hairpins. The rate of coevolution in noncoding pairing region is higher than in coding regions in accordance with selective constraints on substitution rates in coding region.

(Stephan and Kirby, 1993)

Phylogenetic relationships in Drosophila are studied using the Alcohol dehydrogenase locus in several species.

(Thomas and Hunt, 1993)

Upstream element of 1.5kb, located 2-3 kb upstream of Dmul\Adh2 promoter, acts as a transcriptional enhancer. Full enhancer activity can be localised to a 750bp element.

(Falb et al., 1992)

The organization of the Adh gene region in D.hydei is similar to that found in D.mulleri and D.mojavensis. There are three tandem Adh genes: 5' gene is the pseudogene, Dmul\Adh2 and then the 3' gene Dmul\Adh1. Deletion of a nucleotide in the second coodon of each pseudogene suggests that the first duplication occurred before the divergence of the hydei and mulleri subgroups. Comparisons of the extent of sequence divergence propose that independent duplication events generated Dmul\Adh1 and Dmul\Adh2 in the two lineages.

(Menotti-Raymond et al., 1991)

Structure and nucleotide sequence comparisons of Adh genes proposed that an intial duplication of an ancestral Adh gene generated two Adh genes arranged in tandem. The more 5' gene became a pseudogene while the more 3' gene remained functional through all the developmental stages. A second duplication of this 3' gene resulted in 3 genes: a pseudogene, Dmul\Adh2 and Dmul\Adh1.

(Yum et al., 1991)

Dmul\Adh1 and Dmul\Adh2, though structurally distinct from the two-promoter Adh locus, can be regulated by the D.melanogaster trans acting factors.

(Fischer and Maniatis, 1986)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

ADH

(Dorit and Ayala, 1995)

Adh

(Park et al., 2006, Katoh et al., 2000)

Adh-2

(Papaceit et al., 2004, Fischer and Maniatis, 1986)

Adh2

Dmul\Adh2

Name Synonyms

Alcohol dehydrogenase-2

(Moriyama and Hartl, 1993)

alcohol dehydrogenase

(Katoh et al., 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 7 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

X03048

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

CAA26856

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P07160

Other crossreferences

InterPro - A database of protein families, domains and functional sites

References (27)

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