Adh pseudogene
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Dtei\jgw has a chimerical structure; a portion of the sequence is a retrosequence from Adh, which is fused downstream of a group of "recruited" upstream exons. The "recruited" portion of Dtei\jgw has a duplicate copy (Dtei\ymp) in D.teissieri.
Isolated from a D.teissieri genomic library using a D.melanogaster Adh fragment as a probe.
A putative processed "Adh" pseudogene in the sibling species D.teissieri and D.yakuba (FBrf0038647) called "jingwei" by FBrf0059343. Analysis suggested that the "Adh" portion of this gene had retrotransposed in the ancestor of these two species from the "Adh" gene on the second chromosome (FBrf0049662). Within species DNA sequence variation in natural populations suggests that Dtei\jgw is not a pseudogene but is a novel gene: most polymorphisms are silent, polymorphism is at same level for jgw as for typical functional Drosophila genes and no length polymorphism is observed. PCR can detect jgw-specific transcripts, which are expressed sex-specifically in D.teissieri, but not D.yakuba.
Dtei\jgw encodes a pseudogene lacking introns that may have arisen by reverse transcription of RNA.