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FB2026_01
,
released March 12, 2026
ORF3, env
2.072 (northern blot, sequence analysis)
2.1 (northern blot)
483 (aa)
66, 54, 28 (kD observed)
The gypsy env-like protein is glycosylated and
processed, like all retroviral envelope proteins. It is found primarily in
viral particles.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gypsy\env using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Protein is detected in the follicle cells of females of strains permissive for gypsy activity. Expression is not uniform within follicle cells but appears to be concentrated near the oocyte.
The gypsy env-like protein is expressed at high levels in strains in which gypsy elements are active.
JBrowse - Visual display of RNA-Seq signals
View Dmel\gypsy\env in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The expression of gypsy encoded proteins is analysed to explore how gypsy is transmitted between generations. gypsy\env expression is observed in ovaries of flam females and levels of expression are shown to increase as a consequence of a flam mutation. Monoclonal antibodies raised against specific domains of the gypsy\env protein suggests that gypsy\env is processed into surface and trans-membrane proteins.
Production of the gypsy\env message and corresponding protein is strongly repressed by one copy of the non-permissive allele of flam, flamN. A less dramatic reduction in the accumulation of other transcripts and retrotranscripts is also observed. These effects correlate with the inhibition of gypsy transposition in the progeny of these females and is likely to be responsible for this phenomenon. The effects of flam on gypsy\env expression are restricted to the somatic follicle cells that surround the maternal germline.
The protein encoded by gypsy\env is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels and found in viral particles in strains in which gypsy elements are active. Introduction of these particles into strains carrying inactive gypsy elements causes a high level of gypsy insertion activity in the progeny.