U2AF
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\U2af35 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\U2af35 in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Essential splicing factor involved in the choice of tra splice sites in sex determination. Sxl blocks splicing to the non-sex specific, default site in tra by specifically binding to its polypyrimidine tract, blocking the binding of the essential splicing factor U2AF: U2AF then acivates the lower-affinity female-specific site. U2AF has a splicing effector domain that Sxl lacks: addition of this effector domain converts Sxl from a splicing repressor to a splicing activator, rendering it unable to mediate splice-site switching.
Immunological and functional criteria demonstrate U2AF is evolutionarily conserved. U2AF protein activity can replace human U2AF and interact with components of the human pre-mRNA splicing machinery.
A component, with U2AF65, of the U2AF mRNA splicing factor.
