FlyBase Gene Report: Scer\SCEI

General Information

Symbol

Scer\SCEI

Species

S. cerevisiae

Name

SCEI endonuclease

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0027370

Gene Model Status

Not Applicable

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

I-SceI, SceI

Key Links

Foreign Gene Data

Foreign sequence; species == Saccharomyces cerevisiae; gene == SCEI; SGD:S000007279.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Scer\SCEI

Transgenic constructs containing regulatory region of Scer\SCEI

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (6)

Bloomington

97542

w^* P{bamP(898)-CFI}su(Hw)attP8

97543

w^*; wg^Sp-1/CyO, P{Wee-P.ph0}2; P{bamP(898)-CFI}attP2

6934

y¹ w^*; P{70FLP}11 P{70I-SceI}2B sna^Sco/CyO, S²

6935

y¹ w¹¹¹⁸; P{70FLP}23 P{70I-SceI}4A/TM3, Sb¹ Ser¹

25679

y¹ w^*/Dp(2;Y)G, P{hs-hid}Y; P{70FLP}23 P{70I-SceI}4A/TM3, P{hs-hid}14, Sb¹

25680

y¹ w^*/Dp(2;Y)G, P{hs-hid}Y; P{70FLP}11 P{70I-SceI}2B sna^Sco/CyO, P{hs-hid}4

Other Comments

The homing endonuclease gene Scer\SCEI can cause homing in Drosophila, High rates of homing can be achieved within spermatogonia and the female germline. The homed target constructs continue to exhibit homing endonuclease gene activity in the subsequent generation. Homing can be achieved from both the homologous site and (at a lower rate) from an ectopic site.

(Chan et al., 2011)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

I-SceI

(Yannuzzi et al., 2021, Do et al., 2014, Gao et al., 2010, Yu and McVey, 2010, Xu et al., 2009, Johnson-Schlitz et al., 2007, Kracklauer et al., 2007, Takeuchi et al., 2007, LaLonde et al., 2006, Carroll et al., 2002, Handler, 2001, Rong and Golic, 2001, Capecchi, 2000, Bellaiche et al., 1999)

SCEI

SceI

(Cheng et al., 2010, Grönke et al., 2010, Tsuda et al., 2010, Takeuchi et al., 2007, Rong and Golic, 2003)

Scer\SCEI

Name Synonyms

I-SceI endonuclease

(Johnson-Schlitz et al., 2007)

SCEI endonuclease

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 3 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

854590

Other crossreferences

MARRVEL_MODEL - MARRVEL (model organism gene)

854590

SGD - Saccharomyces Genome Database

MOD dbxref

References (43)

Report Sections