Mcp, Mcp silencer
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MCP-PRE using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\MCP-PRE in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Fab-7 and MCP-PRE appear to have two distinct roles; they regulate the expression of their flanking genes in cis, but they also mediate long-distance regulatory interactions with Hox genes in the Antennapedia complex.
The MCP-PRE from the iab-5 region of the Abd-B gene functions as a silencer. A 138bp region within the MCP-PRE is sufficient for silencing. This 138bp fragment contains 4 binding sites for pho protein and 2 binding sites for Trl protein, which are necessary for silencing in vivo.