Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ms(2)n55 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\ms(2)n55 in JBrowsePlease Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Identification: from a natural population.
ms(2)n55 is essential for various processes on the utilization of stored sperm, including proper regulation of the sperm release, capability of sperm entry into the egg, and formation of the male pronucleus.
The ms(2)n55 males produce normal amount of motile sperm and are transferred to females by copulation, but no progeny are produced by the females crossed to the ms(2)n55 males. Immediately after copulation, the ms(2)n55 sperm are stored normally in sperm storage organs of the females and the stored sperm are released along ovulation. Far excessive numbers of sperm are released at each ovulation, so that the stored sperm are used up in a few days after copulation. Although large quantities of sperm are used at each ovulation, only 20% eggs laid are inseminated, indicating that the rate of sperm entry into eggs is significantly low. Furthermore, the ms(2)n55 sperm failed to get decondensed and form a pronucleus, even when they could enter the eggs.
Homozygous mutant males are sterile, producing a normal amount of motile sperm that are capable of being transferred to the female upon copulation, but almost completely fail to produce progeny. The mutant sperm enter the female sperm storage organs but are lost by a few days after copulation because large numbers of sperm are released at each ovulation. Mutant sperm that do enter eggs show a defect in fertilisation; they fail to form male pronuclei.
