FB2026_03 , released September 17, 2026
Human Disease Model Report: familial adenomatous polyposis
Open Close
General Information
Name
familial adenomatous polyposis
FlyBase ID
FBhh0000122
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as familial adenomatous polyposis (FAP). FAP is a genetically heterogeneous disorder, with multiple genes and mapped loci. A listing of FAP subtypes, as defined by OMIM, may be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Jan. 2016 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: familial adenomatous polyposis
OMIM report
Symptoms and phenotype

Familial adenomatous polyposis (FAP) is a disorder characterized by predisposition to cancer. Affected individuals usually develop hundreds to thousands of adenomatous polyps of the colon and rectum, a small proportion of which will progress to colorectal carcinoma if not surgically treated (Nishisho et al., 1991; pubmed:1651563). [from MIM:175100; 2016.01.14]

(OMIM, 2013-)
Genetics

Familial adenomatous polyposis is a genetically heterogeneous disorder.

(OMIM, 2013-)
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
adenomatous intestinal polyposis
adenomatous polyposis of the colon
APC
familial polyposis of the colon
FAP
FPC
Search term: colon cancer
Search term: colorectal cancer
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (2)