FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: high-sugar diet, cardiomyopathy
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General Information
Name
high-sugar diet, cardiomyopathy
FlyBase ID
FBhh0000482
Disease Ontology Term
Parent Disease
OMIM
Overview

Adult flies fed a high-sugar diet (post-eclosion) exhibit a shorter life-span, cardiac arrhythmia, and progressive deterioration of heart function. These phenotypes are accompanied by fibrosis-like collagen accumulation, insulin signaling defects, and fat accumulation. The reduction in life span is more severe in the presence of reduced insulin or reduced P38 MAPK signaling. Identification of components of affected cellular pathways has been demonstrated, providing potential therapeutic approaches.

[updated Jan. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-sugar diet, cardiomyopathy
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Diabetic cardiomyopathy describes diabetes-associated changes in the structure and function of the myocardium that is not directly attributable to other confounding factors such as coronary artery disease (CAD) or hypertension (Boudina and Abel, 2010; pubmed:20180026).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    cardiomyopathy, diet-induced, high sugar
    diabetic cardiomyopathy
    HS diet, cardiomyopathy
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (20)