FB2026_02 , released June 18, 2026
Human Disease Model Report: high-sugar diet, obesity
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General Information
Name
high-sugar diet, obesity
FlyBase ID
FBhh0000494
Disease Ontology Term
Parent Disease
OMIM
Overview

Flies fed a high-sugar diet at the larval or adult stages develop phenotypes typical of diabetes (see FBhh0000153, FBhh0000496) and phenotypes associated with obesity (this report); cardiomyopathy is also observed (see FBhh0000482). Epigenetic effects of parental diets high in sugar have also been studied in flies, showing increased susceptibility to obesity among offspring of males or females fed a high-sugar diet (see FBhh0001547).

[updated Feb. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-sugar diet, obesity
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    diabesity
    HS diet, obesity
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
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          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
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          Publicly Available Stocks
          References (72)