Puromycin-aminonucleoside (PAN)-induced nephropathy (also described as PAN-induced nephrosis) in rodents is an established model of renal injury. In flies, administration of puromycin aminonucleoside to wild-type larvae induces nephrocyte injury; phenotypic changes are mild, but changes in molecular markers correlate with those observed for nephrosis in mammalian systems. This fly model has been used to support the role of Dmel\Src64B in the development of nephrosis; see kidney disease (postulated), SRC-kinase-related (FBhh0000546).
In the fly, nephrocytes act in a manner analogous to human podocytes: the fly nephrocyte diaphragm functions like the mammalian slit diaphragm to regulate filtration; the nephrocytes may also function in protein reabsorption [reviewed in FBrf0220711 and FBrf0235870; see also the human disease model report 'kidney disease (fly models overview)' FBhh0000738].
[updated Jul. 2018 by FlyBase; FBrf0222196]
Puromycin-aminonucleoside-induced nephrosis in rodents is a well-established model of renal injury. Administration of puromycin aminonucleoside to wild-type larvae induces nephrocyte injury; phenotypic changes are mild, but changes in molecular markers correlate with those observed for nephrosis in mammalian systems.
