FB2026_02 , released June 18, 2026
Human Disease Model Report: polycystic kidney disease
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General Information
Name
polycystic kidney disease
FlyBase ID
FBhh0000559
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as polycystic kidney disease (PKD). PKD is a genetically heterogeneous disorder with multiple causative genes. A list of subtypes, as defined by OMIM, can be found by following the link in the 'Related Diseases' section, below; links to reports for subtypes that have been investigated using fly models are included in the table.

[updated Jun. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: polycystic kidney disease
OMIM report
Symptoms and phenotype

Polycystic kidney disease usually presents with progressive, bilateral, multiple cyst formation in the kidneys; liver cysts and intracranial aneurysm frequently develop. Acute and chronic pain, nephrolithiasis, and hypertension are common complications. The most serious renal complication is end-stage renal disease, which occurs in approximately 50% of patients by the age of 60 years. The typical age of onset is in middle life, but the range is from infancy to 80 years (summary by Wu and Somlo, 2000; pubmed:10655152). [from MIM:173900; 2017.06.22]

(OMIM, 2013-)
Genetics

To date, 4 genes have been implicated in polycystic kidney disease. [from MIM:173900; 2017.06.22]

(OMIM, 2013-)
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
PKD
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (5)