FB2026_03 , released September 17, 2026
Human Disease Model Report: thyroid carcinoma, nonmedullary
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General Information
Name
thyroid carcinoma, nonmedullary
FlyBase ID
FBhh0000659
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as nonmedullary thyroid carcinoma (NMTC). A number of different chromosomal rearrangements involving fusions and subsequent activation of the 'rearranged during transfection' (RET) proto-oncogene have been associated with nonmedullary (or papillary) thyroid carcinoma. Drosophila models of this disease make use of several RET fusion constructs: CCDC6-RET fusion (FBhh0000661) and NCOA4-RET fusion (FBhh0000662).

[updated Nov. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: thyroid carcinoma, nonmedullary
OMIM report
Symptoms and phenotype

Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. Papillary thyroid cancer (PTC) is the most common histologic subtype (summary by Vriens et al., 2009; pubmed:20001717). PTCs smaller than 1 cm are referred to as papillary microcarcinomas; these tumors have been identified in up to 35% of individuals at autopsy, suggesting that they may be extremely common, although rarely clinically relevant (summary by Bonora et al., 2010; pubmed:20628519). [from MIM:188550; 2017.11.24]

(OMIM, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
NMTC
non-medullary thyroid carcinoma, papillary
papillary carcinoma of thyroid
papillary thyroid carcinoma
PTC
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
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        Publicly Available Stocks
        Selected Drosophila transgenes
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        Transgene
        Publicly Available Stocks
        RNAi constructs available
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        Publicly Available Stocks
        Selected Drosophila classical alleles
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        Publicly Available Stocks
        References (3)