FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: cancer, multiple, RAS-CSK(SRC)-related with high-sugar diet
Open Close
General Information
Name
cancer, multiple, RAS-CSK(SRC)-related with high-sugar diet
FlyBase ID
FBhh0000665
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes a disease model in Drosophila that allows assessment of the impact of a high-sugar diet on development of cancer. See the human disease model report for 'cancer, multiple, RAS-CSK(SRC)-related' (FBhh0000664) for a description of the RAS-CSK(SRC) cancer model system in flies.

Under a regimen of high dietary sugar, most tissues display insulin pathway abnormalities, including insulin resistance. However, RAS-CSK(SRC) tumors retain insulin pathway sensitivity; they exhibit increased ability to import glucose and resistance to apoptosis. Under a normal dietary regimen, expression of RAS-CSK(SRC) typically results in localized overgrowth; under the high-sugar regimen, significantly larger, more aggressive tumors and metastasis-like phenomena are observed. The role of the WNT signaling pathway in this process has been studied.

A similar transition to a more aggressive proliferative phenotype has been observed using an EGFR model of epithelial cancer combined with a high sugar diet (see FBhh0000932).

[updated Jul. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, multiple, RAS-CSK(SRC)-related with high-sugar diet
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    high-sugar diet, cancer
    HS diet, cancer
    Search term: cancer, epithelial
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (29)