This report describes general characteristics of the group of diseases classified as spastic ataxia (SPAX). Spastic ataxia is a genetically heterogeneous disorder, with multiple genes and mapped loci. A listing of SPAX subtypes can be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models. A comprehensive list of SPAX subtypes, as defined by OMIM, can be found by following the link in the "OMIM phenotypic series" section, below.
[updated Jan. 2021 by FlyBase; FBrf0222196]
Hereditary spastic ataxia comprises a heterogeneous group of progressive neurodegenerative disorders characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance. [from MIM:108600; 2021.01.11]
There are both autosomal recessive and autosomal dominant forms of spastic ataxia. [from MIM:PS108600; 2021.01.11]
