FB2026_03 , released September 17, 2026
Human Disease Model Report: obesity, susceptibility to (postulated), neurotensin-related
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General Information
Name
obesity, susceptibility to (postulated), neurotensin-related
FlyBase ID
FBhh0001329
Disease Ontology Term
Parent Disease
OMIM
Overview

The human NTS gene encodes the precursor for two peptides, neurotensin (NT) and neuromedin N. Work done in mice implicates neurotensin in regulation of fat absorption. In order to expand upon findings in mice, the human Hsap\NTS gene has been introduced into flies. Although a gene ortholgous to NTS has not been identified in flies, there is evidence that the human NT peptide interacts with the Drosophila G-protein coupled receptor PK1-R.

After targeted expression of NTS in Drosophila midgut enteroendocrine cells, mature NT peptide was detected in the larval gut. Increased lipid accumulation was observed in the midgut of both larvae and adults, and in fat body and oenocytes of third instar larvae. Based on additional experiments, it is postulated that the effects of NT on lipid absorption are mediated, in part, through regulation of AMPK (AMP-activated protein kinase; see Dmel\AMPKα).

[updated Mar. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: obesity, susceptibility to (fly models overview)
Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)
Specific Disease Summary: obesity, susceptibility to (postulated), neurotensin-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

The NTS gene encodes the precursor for two peptides, neurotensin and neuromedin N. Neurotensin (NT) is a brain and gastrointestinal peptide that acts on several subtypes of neurotensin receptor (NTSR1, NTSR2, NTSR3). [Gene Cards, NTS; 2021.03.21]

(FlyBase Curators, 2013-)
External links
Disease synonyms
obesity, susceptibility to (postulated), NT-related
Ortholog Information
Human gene(s) in FlyBase
Human gene (HGNC)
Symbol / Name
NTS; neurotensin
D. melanogaster ortholog (based on DIOPT)
Comments on ortholog(s)

No gene orthologous to NTS has been identified in Drosophila.

Other mammalian ortholog(s) used
    D. melanogaster Gene Information (0)
    Other Genes Used: Viral, Bacterial, Synthetic (0)
      Summary of Physical Interactions (0 groups)
      Alleles Reported to Model Human Disease (Disease Ontology) (1 alleles)
      Hsap\NTS
      Models Based on Experimental Evidence ( 1 )
      Allele
      Disease
      Evidence
      References
      Hsap\NTSUAS.cLa
      model of  obesity
      CEA
      (Li et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Alleles Representing Disease-Implicated Variants
      Genetic Tools, Stocks and Reagents
      Sources of Stocks
      Contact lab of origin for a reagent not available from a public stock center.
      Bloomington Stock Center Disease Page
      Related mammalian, viral, bacterial, or synthetic transgenes
      Allele
      Transgene
      Publicly Available Stocks
      Hsap\NTSUAS.cLa
      P{UAS-hNTS.L}
      Hsap\NTSTk.PL
      PBac{Tk-hNTS.L}
      Selected Drosophila transgenes
      Allele
      Transgene
      Publicly Available Stocks
      RNAi constructs available
      Allele
      Transgene
      Publicly Available Stocks
      Selected Drosophila classical alleles
      Allele
      Allele class
      Mutagen
      Publicly Available Stocks
      References (4)