FB2026_02 , released June 18, 2026
Human Disease Model Report: anesthesia, response and mechanisms
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General Information
Name
anesthesia, response and mechanisms
FlyBase ID
FBhh0001375
Disease Ontology Term
    Parent Disease
    OMIM
    Overview

    Many aspects of response to anesthesia have been investigated in Drosophila, using a wide spectrum of anesthetics. References associated with this report typically address general parameters of the response. See the 'Related Diseases' section below for reports of specific genes involved in response to anesthesia.

    See also the FlyBase chemical reports for isoflurane (FBch0000347), sevoflurane (FBch0000349), halothane (FBch0000344), propofol (FBch0000881), desflurane (FBch0000346), enflurane (FBch0000345), methoxyflurane (FBch0000348), xenon (FBch0001060), chloroform (FBch0001062), dinitrogen oxide (FBch0001063), sulfur hexafluoride (FBch0001064).

    [updated Mar. 2024 by FlyBase; FBrf0222196]

    Disease Summary Information
    Disease Summary: anesthesia, response and mechanisms
    OMIM report
    Human gene(s) implicated
    Symptoms and phenotype

    Volatile general anesthetics (VAs) are simple organic compounds that rapidly and reversibly suppress responsiveness to external stimuli in all animals, while at the same time leaving basal functions intact.

    (FlyBase Curators, 2013-)
    Genetics
    Cellular phenotype and pathology
    Molecular information

    Nitrous oxide, halothane, isoflurane, desflurane, and sevoflurane are the most commonly used inhalation anesthetics in practice today. [Gene Reviews, Inhalational Anesthetic; 2021.07.14]

    (FlyBase Curators, 2013-)
    External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (31)