FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: colorectal cancer, personalizable in silico model
Open Close
General Information
Name
colorectal cancer, personalizable in silico model
FlyBase ID
FBhh0001382
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes a computational framework in the form of an in silico Drosophila Patient Model (DPM) for developing personalized drug combinations for colorectal cancer (CRC) patients. Five molecular network models of cells regulating the maintenance of adult Drosophila midgut epithelium lining were constructed: multipotent intestinal stem cells (ISCs), enteroblasts (EBs), enterocytes (ECs), enteroendocrine cells (EEs), and visceral muscle (VM) cells. Using specific CRC cases, results obtained from the in silico DPM analyses helped to elucidate cell fate evolution in colorectal tumorigenesis, to validate cytotoxicity of nine FDA-approved CRC drugs, and to devise optimal personalized treatment using drug combinations.

[updated Aug. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: colorectal cancer, personalizable in silico model
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    CRC in silico Drosophila Patient Model
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (3)