FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: organophosphate-induced delayed neuropathy
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General Information
Name
organophosphate-induced delayed neuropathy
FlyBase ID
FBhh0001385
Disease Ontology Term
Parent Disease
OMIM
Overview

Treating flies with the organophosporous compound tri-ortho-cresyl phosphate (TOCP) results in locomotor deficits and neurodegeneration two weeks after exposure, symptoms similar to organophosphate-induced delayed neuropathy (OPIDN). An acute neurotoxicity is also observed: primary neurons showed signs of axonal degeneration within an hour after treatment. This system has been used to investigate the role of the Drosophila ortholog of PNPLA6, sws, in the development of OPIDN symptoms. Changes in levels of expression of Dmel\sws and Dmel\Pka-C3 (known to interact with sws) were found to impact the delayed symptoms of OPIDN, but not the acute toxicity.

See also the Human Disease Model report 'neurodegenerative disease, PNPLA6-related' (FBhh0000368) and the FlyBase chemical report for Tri-O-cresyl phosphate (FBch0001061).

[updated Mar. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: organophosphate-induced delayed neuropathy
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Certain organophosphorus (OP) compounds produces OP compound-induced delayed neurotoxicity (OPIDN), a distal degeneration of axons in the central nervous system and peripheral nervous system (Richardson et al., 2020; pubmed:32518884).

(FlyBase Curators, 2013-)
Genetics

OPIDN is caused by inhibition of the PNPLA6 (formerly NTE) gene product by the organophosphate (Richardson et al., 2020; pubmed:32518884).

(FlyBase Curators, 2013-)
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    OPIDN
    OPIDP
    organophosphate-induced delayed polyneuropathy
    organophosphorus compound-induced delayed neurotoxicity
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (4)