FB2026_02 , released June 18, 2026
Human Disease Model Report: seizure sensitivity, disruption during critical developmental period
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General Information
Name
seizure sensitivity, disruption during critical developmental period
FlyBase ID
FBhh0001437
Disease Ontology Term
Parent Disease
OMIM
Overview

A critical period of late embryonic development in Drosophila has been determined during which manipulation of neural activity is sufficient to significantly influence seizure behavior at postembryonic stages. Increasing neuronal excitation during this period in wild-type animals is sufficient to permanently induce seizure-sensitive behavior. In a seizure-sensitive genotype, inhibition of elevated activity during the critical period is sufficient to suppress seizure sensitivity in later stages.

Using mutations of Dmel\Nos and pharmaceutical interventions, nitric oxide signaling has been identified as a key mediator of neural activity during this period.

[updated Feb. 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: seizure sensitivity, disruption during critical developmental period
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    seizure sensitivity, disruption during developmental critical window
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
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          Publicly Available Stocks
          References (3)