FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: liver disease (fly models overview)
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General Information
Name
liver disease (fly models overview)
FlyBase ID
FBhh0001458
Disease Ontology Term
Parent Disease
OMIM
Overview

This report includes links to reviews and general information on fly models of liver disease. In vertebrates, the liver is a critical organ for the maintenance of body homeostasis; it controls several molecular and metabolic routes and acts in detoxification processes. In insects, these functions are carried out in the fat body and in oenocytes; the fat body appears to control hepatic functions related to feeding, while the oenocytes regulate functions related to fasting.

References describing biology of this Drosophila system: Moraes and Montagne, 2021 (FBrf0251472).

[updated May 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: liver disease (fly models overview)
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    hepatic disorder
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (2)