FB2026_03 , released September 17, 2026
Human Disease Model Report: progeroid syndrome
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General Information
Name
progeroid syndrome
FlyBase ID
FBhh0001512
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as progeria. Progeria is a genetically heterogeneous disorder with multiple implicated genes that appear to confer susceptibility to the disease. A listing of progeria subtypes, as defined by OMIM, may be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Apr. 2023 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: progeroid syndrome
OMIM report
Symptoms and phenotype

Progeroid syndromes arecharacterized by the premature onset of age-related pathologies.

(FlyBase Curators, 2013-)

Progeria is characterized lipodystrophy or lipoatrophy, osteolysis, facial features resembling those of aged persons, and other characteristics associated with aging observed children or young adults. [from MIM:176670, MIM:614008; 2023.04.03]

(OMIM, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (2)