FB2026_03 , released September 17, 2026
Human Disease Model Report: night blindness, congenital stationary
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General Information
Name
night blindness, congenital stationary
FlyBase ID
FBhh0001560
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as congenital stationary night blindness (CSNB). Congenital stationary night blindness is a genetically heterogeneous disorder, with multiple genes and mapped loci. A listing of CSNB subtypes, as defined by OMIM, may be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Feb. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: night blindness, congenital stationary
OMIM report
Symptoms and phenotype

Congenital stationary night blindness (CSNB) is a clinically and genetically heterogeneous group of nonprogressive retinal disorders that can be characterized by impaired night vision, decreased visual acuity, nystagmus, myopia, and strabismus. CSNB can be classified into 2 groups based on electroretinography (ERG) findings: the Schubert-Bornschein type is characterized by an ERG in which the b-wave is smaller than the a-wave, whereas the Riggs type is defined by proportionally reduced a- and b-waves. In addition, Schubert-Bornschein CSNB is associated with decreased visual acuity, myopia, and nystagmus, whereas in Riggs CSNB patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus (summary by Riazuddin et al., 2010, pubmed:20850105). Additionally, Schubert-Bornschein CSNB can be subdivided into 'complete' and 'incomplete' forms (summary by Riazuddin et al., 2010), pubmed:20850105) [from MIM:310500; 2024.02.21]

(OMIM, 2013-)
Genetics

CSNB is a genetically heterogeneous disorder, with several causative genes and mapped loci. [from MIM:310500; 2024.02.21]

(OMIM, 2013-)
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
congenital essential nyctalopia
congenital stationary night blindness
CSNB
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (2)