FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Egfr
FlyBase ID
FBig0000085977
Interaction Network
Interactions Browser links
Egfr network
Reported Interactions
FBrf0178972-2.coIP.WB
Reference
Alvarado et al., 2004
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S3
Participants
Corresponds to
Reported as
Role
Note
Egfr 

Egfr

bait

GFP tag

Egfr 

Egfr

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S3 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Alvarado et al., 2004)
FBrf0211632-3.SPA
Reference
Alvarado et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Egfr 

dEGFR

self
Egfr 

dEGFR

self
Egfr 
Egfr 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Egfr 
extracellular region
unspecified role

s-dEGFR

Egfr 
domain II
unspecified role
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Mutations in domain II that compromise dimerization of the Egfr protein (\'s-dEGFR[dim-arm]\') appear to abolish the negative cooperativity observed in reaction with spi protein.

(Alvarado et al., 2010)
External Crossreferences and Linkouts ( 0 )
References (2)