FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000095787
Interaction Network
Interactions Browser links
pum network
Sos network
Reported Interactions
FBrf0218126-4.Y3H
Reference
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
pum 

Pum

bait

fused to LexA DNA-binding domain

pum 
Sos 

sos

prey

dimerized, fused to MS2 RNA-stem loop

Sos 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
pum 
Puf region
sufficient binding region
aa 1093-1427
Sos 
NRE
sufficient binding region
nt 5568-5574

coordinates relative to Sos-RA isoform

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

yeast LexA/GAL4-AD.

pum binds 3\' UTR NRE consensus sequences (UGUANAUA) in hb, Egfr, rl, Sos and drk, but not in phl (also known as raf).

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)