FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
pll, cher, Tl
FlyBase ID
FBig0000098264
Interaction Network
Interactions Browser links
pll network
cher network
Tl network
Reported Interactions
FBrf0099196-15.Y2H
Reference
Edwards et al., 1997
Description
physical association
Assay
Collection
Source/Stage
ovary / adult stagefemaleorganism / embryonic stage 1embryonic stage 15blastoderm stagegastrula stageembryonic stage 8embryonic stage 9embryonic stage 6early extended germ band stageembryonic cycle 3extended germ band stageembryonic stage 4embryonic stage 2embryonic cycle 9late extended germ band stageembryonic stage 5embryonic stage 12embryonic stage 11embryonic stage 3embryonic cycle 6embryonic cycle 8embryonic cycle 5embryonic cycle 7embryonic stage 13embryonic cycle 4embryonic stage 14embryonic stage 10embryonic stage 7
Cell line used
Participants
Corresponds to
Reported as
Role
Note
pll 

Toll

bait

fused to LexA DNA-binding domain

cher 

Filamin

prey

fused to B42 activation domain

cher 
Tl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Tl 
intracellular domain
sufficient binding region
aa 829-1036

lacks putative inhibitory domain (aa 1037-1097)

cher 
C-terminal region
sufficient binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey from ovary and embryo cDNA expression library).

(Edwards et al., 1997)

Two-hybrid system: yeast LexA-BD/B42-AD

(Edwards et al., 1997)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)