FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Su(var)3-3, His3
FlyBase ID
FBig0000103235
Interaction Network
Interactions Browser links
Su(var)3-3 network
His3 network
Reported Interactions
FBrf0204799-1.ENZ.MS
Reference
Rudolph et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Su(var)3-3 

SU(VAR)3-3

bait

FLAG tag, HA tag

Su(var)3-3 
His3 

His3

prey
His3 
His3 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Su(var)3-3 
amine oxidase domain
mutation disrupting interaction
aa 316

G316R, mutation as found in Su(var)3-3[9] allele

His3 
histone tail
necessary binding region
aa 1-20

H3K4me1 or H3K4me2

His3 
H3K4me1, H3K4me2
necessary binding region
aa 4
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; enzyme produced as a recombinant fusion protein in Sf9 baculovirus system; enzyme target chemically synthesized.

(Rudolph et al., 2007)

Su(var)3-3 demethylates mono- and dimethylated H3-K4.

(Rudolph et al., 2007)
External Crossreferences and Linkouts ( 0 )
References (1)