FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Lar, InR
FlyBase ID
FBig0000103414
Interaction Network
Interactions Browser links
Lar network
InR network
Reported Interactions
FBrf0215568-1.ENZ
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Lar 

DLAR

enzyme

His tag

Lar 

DLAR

enzyme

His tag

Lar 
InR 

Insulin Receptor peptide

enzyme target

phosphopeptide

InR 

Insulin Receptor peptide

enzyme target

phosphopeptide

InR 
InR 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0215568-9.SPR
Reference
Madan et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Lar 

DLAR

bait

His tag

Lar 
Lar 
InR 

Insulin Receptor peptide

prey

phosphopeptide

InR 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Lar 
D1 PTP domain
unspecified role
aa 1496-1731
Lar 
D2 PTP domain
unspecified role
aa 1760-2022
InR 
phosphotyrosine region
unspecified role
aa 1541-1551

TRDIpYETDYYR

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Enzyme expressed and purified from bacteria.

(Madan et al., 2011)

Enzyme target derived from chemical synthesis.

(Madan et al., 2011)

Each of the D1 and D2 PTP domains can bind phosphopeptides independently, but with slightly different sequence specificities..

(Madan et al., 2011)
FBrf0244365-1.coIP.WB
Reference
Kaur et al., 2019
Description
physical association
Assay
Collection
Source/Stage
organism / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
InR 

InR

bait
Lar 

Lar

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larvae of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Kaur et al., 2019)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)