FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000104124
Interaction Network
Interactions Browser links
His4 network
fs(1)h network
Reported Interactions
FBrf0231041-3.PD.WB
Description
physical association
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
His4 

H4

bait

biotin tag, acetylated at K5, K8, K12 and K16

His4 

FSH

prey

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
bromodomains 1 and 2
sufficient binding region
aa 1-587
His4 
N-terminal tail
sufficient binding region
aa 1-19
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait chemically synthesized; prey produced as a recombinant fusion protein in bacterial system.

fs(1)h binds acetylated His4 peptides more strongly than unmodified peptides. Binding of fs(1)h to His4 is also inhibited by the BET bromodomain inhibitor JQ1.

External Crossreferences and Linkouts ( 0 )
References (1)