FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
His2Av, Su(var)205
FlyBase ID
FBig0000104359
Interaction Network
Interactions Browser links
His2Av network
Su(var)205 network
Reported Interactions
FBrf0227589-1.coIP.WB
Reference
Vernì and Cenci, 2015
Description
physical association
Assay
Collection
Source/Stage
larval central nervous system / third instar larval stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
His2Av 

H2A.V

bait

GFP tag

Su(var)205 

HP1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was central nervous system extract of third instar larvae; bait produced from transgenic gene; prey produced from endogenous gene.

(Vernì and Cenci, 2015)
FBrf0227589-2.PD.WB
Reference
Vernì and Cenci, 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Su(var)205 

HP1

bait

GST tag

Su(var)205 
His2Av 

H2A.V

prey

GFP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Su(var)205 
CD domain
mutation disrupting interaction
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transgenic construct isolated from third instar larval central nervous system.

(Vernì and Cenci, 2015)

Deletion of the CD domain of Su(var)205 disrupts the interaction with His2Av.

(Vernì and Cenci, 2015)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)